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Bacterial senescence : ウィキペディア英語版 | Bacterial senescence
Bacterial senescence or bacterial aging refers to the gradual decrease in cellular function in individual bacterium as they increase in age. Indicators of senescence include a decelerated division rate and an increase likelihood of death. The fundamental cause of aging in bacteria is thought to be the accumulation of deleterious components (aging factors). Asymmetrically dividing bacteria, such as Caulobacter ''crescentus'', show signs of replicative aging. Recent evidence also shows that the symmetrically dividing bacteria, Escherichia ''coli'', exhibit signs of replicative aging caused by subtle asymmetries in its division. == Factors contributing to aging== Aging factors can be defined as irreparable damages to cellular components which ultimately contribute to the decreased fitness of the individual harbouring them. Putative aging factors include damaged DNA strands, old cell-surface material, and mis-folded or aggregated protein. The cell poles of replicating E. ''coli'' are often used as a proxy for aging factors as each bacterium inherits an old cell-pole (mother’s pole) and a newly synthesized new cell-pole. Inclusion bodies, masses of aggregated damaged or mis-folded proteins, have recently been shown to contribute to the aging of cellular organisms.
Senescence in single celled organisms is thought to arise via the asymmetric partitioning of aging factors between daughter cells. It has long been argued that, on theoretical grounds, the preferential segregation of damage in unicellular organisms would contribute to the fitness of the overall population.〔Kirkwood, T. B. L. (1981). Repair and its evolution: survival versus reproduction. Physiological Ecology ; an Evolutionary Approach to Resource Use.〕 The single celled eukaryotic organism, Sacchoaromyces ''cerevisiae'', retains deleterious aging factors in the mother cell leading to rejuvenation of the daughter.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Bacterial senescence」の詳細全文を読む
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